Administrative Supplements


We are pleased to share the FY2023 CFAR Administrative Supplement opportunity. Please review the announcement and the LOI guidelines below for details. 

Important SD CFAR Submission Processes and Deadlines 

Each CFAR is allowed to submit a maximum of two supplement applications for Topics #1-3. Two applications can be in the same topic area. Clinical trials are not permitted. Please submit a Letter of Intent (LOI) no longer than 2 pages to the SD CFAR Administrative Core ( by 12:00 pm PT on Friday, March 10. Attached is the LOI guidance. Submitted LOIs will undergo review by SD CFAR leadership and the final two (2) proposals will be selected for submission.


The purpose of this administrative supplement opportunity is to support innovative research projects (#1-3) that address key gaps in HIV/AIDS and will advance the field. This opportunity should build research capacity and be consistent with the recent NIH HIV/AIDS research priorities (NOT-OD-20-018). Research involving populations experiencing health disparities is encouraged (African Americans, Latinos/Hispanics, American Indians and Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, less privileged socioeconomic groups, underserved rural populations, and sexual and gender minorities).


  1. Formative, intervention, and implementation research to explore delivery of long-acting PrEP in populations who may benefit - max funding of up to $150,000 Direct Costs 
  2. HIV and co-morbidities: Identification of mechanisms and strategies for optimal care that also reduce disparities - max funding of up to $150,000 Direct Costs
  3. Community-led research topic - max funding of up to $150,000 Direct Costs 

In summary, a total of up to two (2) applications for Topics #1 – 3 will be submitted to NIAID through the SD CFAR Administrative Core.

Investigator Eligibility

Project leaders for all scientific areas of interest (Topics #1-3) are restricted to early career investigators who have never received an R01-equivalent, P-series or U-series research grants, and established investigators new to HIV. Post-doctoral fellows are eligible to apply if they will assume a faculty position by the time the supplement project and funding begins. Studies that are a continuation of previously funded CFAR supplements or funded NIH applications that do not address new specific aims are not eligible for funding under this announcement. Additionally, a proposed supplement application that is linked to a proposed application not yet funded is not eligible for funding under this announcement. 



Application Timeline


Friday, March 10 by 12 pm PT LOIs due to for Topics 1 - 3
Thursday, March 16 Notifications to applicants re: finalists
Thursday, April 6 Final applications due to the SD CFAR Admin Core
Monday, April 10 After review by the Admin Core, Admin Core submits final applications for UCSD institutional review (HSSPPO)
Monday, April 17 Applications due @ NIH


Letter of Intent Guidelines


Click here to download a pdf of Letter of Intent Guidelines


Preferred length: Two pages. Please be as succinct as possible. References may be placed on a separate page.

Preferred format: Use at least half-inch margins on all sides, and 11-point type or larger in the body of your letter. Headers and footers may have smaller type if it is legible. No tables or figures, please.

Basic information (not included in 2-page limit):

1. Supplement PI name, academic title, email address, and SD CFAR institution 

2. List of other proposed Senior/Key Personnel

3. Supplement Topic

4. Project Title

5. Project/Performance Site location(s)

Preferred content:

State and define the following:

  • Problem/research question: What do you wish to study and why? Provide background information and list previous research in this area if possible.
  • Objectives: What will the proposed research accomplish?
  • Specific Aims: State each Aim using active verbs, then define how you propose to achieve it. Please also state your hypothesis/hypotheses for each Aim. Indicate how the proposed activities outlined in the supplement announcement are expected to support your Specific Aims.
  • Implementation Science Framework: Provide a brief description of the implementation science framework or model you plan to utilize.
  • Inter-CFAR Synergy: Include a statement of how you plan to utilize existing SD CFAR resources (including Cores and the EHE SWG) and/or develop unique expertise, technology, and resources at SD CFAR institutions.
  • Human or animal subjects’ involvement: Describe any research to be done in enrolled participants. If using stored specimens, how were they obtained and where are they stored? Do you need or have IRB or IACUC approval? If your study does not involve human or animal subjects, skip to Next Steps.
  • Next steps: How will you use the data resulting from this proposed research?


Please refer to deadlines above and note there is a tight turnaround time to submit final applications. The earliest anticipated start date for projects is July 1, 2023.



Background on NIH Administrative Supplements

NIH occasionally announces opportunities for administrative supplements. These are grants in specific aspects of HIV research that are offered to all CFAR sites for periods of one or more years. They are considered supplemental funding to the sites' CFAR grant.

When we are informed of a new administrative supplement, we announce the opportunity and application instructions by email to our members.

We hope you will apply for one of these supplements. Please remember to acknowledge the San Diego CFAR in any publication that results from one of our grant opportunities.

At a Glance